Bifidobacterium animalis subsp. lactis – BS01 (LMG P-21384)

DAILY DOSAGE IN CLINICAL STUDY
1) 5 billion CFU
2) 10 billion CFU
3) 5 billion CFU
4) 5 billion CFU uncoated and 1 billion cells microencapsulated

FUNCTIONALITY
Constipation • Intestinal transit • Reduction of gastrointestinal discomfort • Leaky gut

Human clinical trials
1) Del Piano M. et al. The use of probiotics in healthy volunteers with evacuation disorders and hard stools. A double blind, randomized, placebo-controlled study. J Clin Gastroenterol, 2010; 44(8):S30-34.
2) Del Piano M. et al. The use of probiotics in the treatment of constipation in the elderly. CIBUS, 2005; 1(1):23-30.
3) Dimidi E. et al. The effect of probiotics on functional constipation in adults: a systematic review and metanalysis of randomized controlled trials. Am J Clin Nutr 2014;100:1075–84.
4) Del Piano M. et al. Comparison of the Kinetics of Intestinal Colonization by Associating 5 Probiotic Bacteria Assumed Either in Microencapsulated or in a Traditional, Uncoated Form. J Clin Gastroenterol 2012;46:S85-S92.

FUNCTIONALITY
Strengthening of natural defences and natural immunity

In vitro study
Mogna L. et al. Micronized Cells of the Probiotic Strain Bifidobacterium lactis BS01 Activate Monocyte Polarization: A New Approach. J Clin Gastroenterol. 2018;52:S57-S61.

DAILY DOSAGE IN CLINICAL STUDY
2.5 billion CFU + 2.5 billion CFU + 2.5 billion CFU + 2.5 billion CFU + 5 billion CFU + FOS or GOS

FUNCTIONALITY
Reinforcement of the natural defences • Reduction of the intestinal discomfort • Rebalance of the intestinal microbiota

Human clinical trial
1) Pregliasco F. et al. A New Chance of Preventing Winter Diseases by the Administration of Symbiotic Formulations. Journal of Clinical Gastroenterology, 2008; 42(2): 224-233.
2) Belcaro G. et al. Prevention of flu episodes with colostrum and Bifivir compared with vaccination: an epidemiological, registry study. Panminerva Medica 2010;52:269-75.

In vitro study
Mogna L. et al. Micronized Cells of the Probiotic Strain Bifidobacterium lactis BS01 Activate Monocyte Polarization: A New Approach. J Clin Gastroenterol. 2018;52:S57-S61.

DAILY DOSAGE IN CLINICAL STUDY
10 billion CFU + 10 billion CFU + 10 billion CFU + 3g

FUNCTIONALITY
Reinforcement of the natural defences • Reduction of the incidence, severity and duration of Acute Respiratory Infections (ARI) during the cold season

Human clinical trial
Pregliasco F. et al. A New Chance of Preventing Winter Diseases by the Administration of Symbiotic Formulations. Journal of Clinical Gastroenterology, 2008; 42(2): 224-233.

In vitro study
Mogna L. et al. Micronized Cells of the Probiotic Strain Bifidobacterium lactis BS01 Activate Monocyte Polarization: A New Approach. J Clin Ga- stroenterol. 2018;52:S57-S61.

DAILY DOSAGE IN CLINICAL STUDY
1 billion

FUNCTIONALITY
Atopic dermatitis

Human clinical trial
Manzotti G. et al. Probiotics as a Novel Adjuvant Approach to Atopic Dermatitis. Journal of Contemporary Immunology (2014) Vol. 1 No. 2 pp. 57-66.

FUNCTIONALITY
Antioxidant activity • Reduced glutathione (GSH) and superoxide dismutase (SOD) production

Internal in vitro data available upon request on above-mentioned functions and strains

DAILY DOSAGE IN CLINICAL STUDY
GG 25 billion CFU + BS01 15 billion CFU + BR03 5 billion CFU + BL03 5 billion CFU

FUNCTIONALITY
Sleep improvement and cognitive symptoms improvement in patients with encephalomyelitis/chronic fatigue syndrome

Human clinical trial
Wallis A. et al. Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis / chronic fatigue syndrome: neuropsychological symptoms and sex comparisons. J Transl Med 2018, 16:24.